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Adoptive transfer of tumor cytotoxic macrophages generated in vitro from circulating blood monocytes: a new approach to cancer immunotherapy

Andreesen, Reinhard and Scheibenbogen, C. and Brugger, W. and Krause, S. and Meerpohl, H. G. and Leser, H. G. and Engler, H. and Löhr, G. W. (1990) Adoptive transfer of tumor cytotoxic macrophages generated in vitro from circulating blood monocytes: a new approach to cancer immunotherapy. Cancer research 50 (23), pp. 7450-6.

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Abstract

Cells of the macrophage lineage are considered to be of special importance in the defense of the host against tumor development and spread. Immunotherapeutic strategies to stimulate macrophage (MAC) tumor cytotoxicity make use of activating compounds such as gamma-interferon which are given systemically. However, there are several lines of evidence that in malignant disease the generation of ...

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Item Type:Article
Date:1990
Institutions:Medicine > Abteilung für Hämatologie und Internistische Onkologie
Identification Number:
ValueType
1701343PubMed ID
Classification:
NotationType
AdultMESH
AgedMESH
Biopterin/secretionMESH
Blood TransfusionMESH
Carcinoma/therapyMESH
Cell DifferentiationMESH
Centrifugation, Density GradientMESH
Dose-Response Relationship, DrugMESH
Fibronectins/secretionMESH
Granulocyte-Macrophage Colony-Stimulating Factor/secretionMESH
HumansMESH
Immunotherapy, Adoptive/adverse effectsMESH
Injections, IntraperitonealMESH
Injections, IntravenousMESH
Interferon-gamma, Recombinant/pharmacologyMESH
Interleukin-6/secretionMESH
Macrophages/transplantationMESH
MaleMESH
Melanoma/therapyMESH
Middle AgedMESH
Monocytes/drug effectsMESH
Neoplasms/therapyMESH
NeopterinMESH
Transplantation, AutologousMESH
Tumor Necrosis Factor-alpha/secretionMESH
alpha-Macroglobulins/secretionMESH
Subjects:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Universitätsbibliothek Regensburg
Deposited On:14 Apr 2010 05:37
Last Modified:14 Apr 2010 05:37
Item ID:14256
Owner Only: item control page
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