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The polysulphated polyxylan Hoe/Bay-946 inhibits HIV replication on human monocytes/macrophages

von Briesen, H. and Meichsner, C. and Andreesen, Reinhard and Esser, R. and Schrinner, E. and Rübsamen-Waigmann, H. (1990) The polysulphated polyxylan Hoe/Bay-946 inhibits HIV replication on human monocytes/macrophages. Research in virology 141 (2), pp. 251-7.

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Abstract

Due to the important role of monocytes/macrophages in the pathogenesis of AIDS, potential drugs with anti-HIV activity in lymphocytes must also be effective in monocytes/macrophages. For testing the efficacy of antiviral substances, monocytes/macrophages from peripheral blood were infected, respectively, with highly replicating HIV1 and HIV2 strains, thereby providing an extremely sensitive ...

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Item Type:Article
Date:1990
Institutions:Medicine > Abteilung für Hämatologie und Internistische Onkologie
Identification Number:
ValueType
2345812PubMed ID
Classification:
NotationType
Acquired Immunodeficiency Syndrome/drug therapyMESH
Antiviral Agents/pharmacologyMESH
Cells, CulturedMESH
HIV-1/drug effectsMESH
HIV-2/drug effectsMESH
HumansMESH
Macrophages/microbiologyMESH
Monocytes/microbiologyMESH
Pentosan Sulfuric PolyesterMESH
Polysaccharides/pharmacologyMESH
Virus Replication/drug effectsMESH
Subjects:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Universitätsbibliothek Regensburg
Deposited On:14 Apr 2010 05:29
Last Modified:14 Apr 2010 05:29
Item ID:14262
Owner Only: item control page
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