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Chemomodulation of drugs involved in multidrug resistance in chronic lymphatic leukemia of the B-cell type

Reichle, A. and Diddens, H. and Altmayr, F. and Rastetter, J. and Andreesen, Reinhard (1994) Chemomodulation of drugs involved in multidrug resistance in chronic lymphatic leukemia of the B-cell type. Cancer chemotherapy and pharmacology 34 (4), pp. 307-16.

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Abstract

Reduced drug accumulation may be one reason for intrinsic drug resistance in chronic lymphatic leukemia of the B-cell type (B-CLL). Immunophenotyped leukemic human B-cells from 38 cases of B-CLL were characterized for P-glycoprotein (PGP) content. In all, 30 cases of B-CLL were additionally analyzed for further parameters: accumulation of daunorubicin (DNR, n = 20) and rhodamine 123 (Rh123, n = ...

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Item Type:Article
Date:1994
Institutions:Medicine > Abteilung für Hämatologie und Internistische Onkologie
Identification Number:
ValueType
7913420PubMed ID
Classification:
NotationType
Antineoplastic Agents/pharmacokineticsMESH
Carrier Proteins/analysisMESH
Daunorubicin/pharmacokineticsMESH
Drug ResistanceMESH
Flow CytometryMESH
HumansMESH
ImmunophenotypingMESH
Leukemia, Lymphocytic, Chronic, B-Cell/physiopathologyMESH
Membrane Glycoproteins/analysisMESH
Neoplasm Proteins/analysisMESH
P-GlycoproteinMESH
Rhodamine 123MESH
Rhodamines/pharmacokineticsMESH
Verapamil/pharmacologyMESH
Vincristine/pharmacokineticsMESH
Subjects:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Universitätsbibliothek Regensburg
Deposited On:14 Apr 2010 05:08
Last Modified:14 Apr 2010 05:08
Item ID:14289
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