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111In-oxine labelling of tumour-cytotoxic macrophages generated in vitro from circulating blood monocytes: an in vitro evaluation

Marienhagen, J. and Hennemann, B. and Andreesen, Reinhard and Eilles, C. (1995) 111In-oxine labelling of tumour-cytotoxic macrophages generated in vitro from circulating blood monocytes: an in vitro evaluation. Nuclear medicine communications 16 (5), pp. 357-61.

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Abstract

The labelling of ex-vivo activated macrophages with doses of 111In-oxine sufficient for gamma camera imaging does not damage cell viability or the functional competence of cells (secretion of tumour necrosis factor-alpha and interleukin-6). The mean labelling efficiency was about 84%. Release of 111In equivalent to 15% occurred over 24 h under cell culture conditions, indicating good stability of the radioactive cell label. 111In-oxine-labelled macrophages are a suitable tool for biokinetic studies of adoptive immunotherapy.

Item Type:

Article

Institutions:

Medicine > Abteilung für Hämatologie und Internistische Onkologie

Identification Number:

Value	Type
7659388	PubMed ID

Classification:

Notation	Type
Cell Survival	MESH
Cytotoxicity, Immunologic	MESH
Humans	MESH
Immunotherapy, Adoptive	MESH
Indium Radioisotopes/pharmacokinetics	MESH
Macrophage Activation	MESH
Macrophages/metabolism	MESH
Monocytes/immunology	MESH
Neoplasms/therapy	MESH
Organometallic Compounds/pharmacokinetics	MESH
Oxyquinoline/pharmacokinetics	MESH