Reichle, A. and Diddens, H. and Altmayr, F. and Rastetter, J. and Andreesen, Reinhard (1995) Beta-tubulin and P-glycoprotein: major determinants of vincristine accumulation in B-CLL cells. Leukemia research 19 (11), pp. 823-9.
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Vincristine (VCR) accumulation in chronic lymphatic leukemia of B-cell origin (B-CLL) has recently been shown not to be inversely correlated to P-glycoprotein (PGP) levels. Therefore, we studied, in addition to PGP expression and accumulation of VCR, the cellular beta-tubulin content in quiescent and rhIL-2 activated B-CLL cells. VCR mediates cytotoxicity by binding to tubulin. Constitutive ...
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|Institutions:||Medicine > Abteilung für Hämatologie und Internistische Onkologie|
|Subjects:||600 Technology > 610 Medical sciences Medicine|
|Refereed:||Yes, this version has been refereed|
|Created at the University of Regensburg:||Yes|
|Deposited On:||14 Apr 2010 05:05|
|Last Modified:||14 Apr 2010 05:05|