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Beta-tubulin and P-glycoprotein: major determinants of vincristine accumulation in B-CLL cells

Reichle, A. and Diddens, H. and Altmayr, F. and Rastetter, J. and Andreesen, Reinhard (1995) Beta-tubulin and P-glycoprotein: major determinants of vincristine accumulation in B-CLL cells. Leukemia research 19 (11), pp. 823-9.

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Abstract

Vincristine (VCR) accumulation in chronic lymphatic leukemia of B-cell origin (B-CLL) has recently been shown not to be inversely correlated to P-glycoprotein (PGP) levels. Therefore, we studied, in addition to PGP expression and accumulation of VCR, the cellular beta-tubulin content in quiescent and rhIL-2 activated B-CLL cells. VCR mediates cytotoxicity by binding to tubulin. Constitutive ...

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Item Type:Article
Date:1995
Institutions:Medicine > Abteilung für Hämatologie und Internistische Onkologie
Identification Number:
ValueType
8551799PubMed ID
Classification:
NotationType
AgedMESH
Aged, 80 and overMESH
Antineoplastic Agents, Phytogenic/pharmacokineticsMESH
Blotting, NorthernMESH
Calcium Channel Blockers/pharmacologyMESH
FemaleMESH
HumansMESH
ImmunophenotypingMESH
Interleukin-2/pharmacologyMESH
Leukemia, Lymphocytic, Chronic, B-Cell/metabolismMESH
MaleMESH
Middle AgedMESH
P-Glycoprotein/metabolismMESH
Recombinant Proteins/pharmacologyMESH
Tubulin/metabolismMESH
Tumor Cells, Cultured/metabolismMESH
Verapamil/pharmacologyMESH
Vincristine/pharmacokineticsMESH
Subjects:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Universitätsbibliothek Regensburg
Deposited On:14 Apr 2010 05:05
Last Modified:14 Apr 2010 05:05
Item ID:14294
Owner Only: item control page
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