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Interferon-alpha does not improve the antineoplastic efficacy of high-dose infusional 5-fluorouracil plus folinic acid in advanced colorectal cancer. First results of a randomized multicenter study by the Association of Medical Oncology of the German Cancer Society (AIO)

Köhne, C. H. and Wilke, H. and Hecker, H. and Schöffski, P. and Käufer, C. and Rauschecker, H. and Andreesen, Reinhard and Ohl, U. and Lange, H. J. and Klaassen, U. (1995) Interferon-alpha does not improve the antineoplastic efficacy of high-dose infusional 5-fluorouracil plus folinic acid in advanced colorectal cancer. First results of a randomized multicenter study by the Association of Medical Oncology of the German Cancer Society (AIO). Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 6 (5), pp. 461-6.

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Abstract

BACKGROUND: High-dose 5-FU given weekly as a 24-h infusion in combination with folinic acid (FA) has been associated with low toxicity and a high response rate. Interferon-alpha (IFN) either alone or in combination with FA has also improved treatment results by modulating 5-FU activity. We therefore initiated a randomized multicenter trial comparing the ability of FA or IFN to modulate infusional ...

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Item Type:Article
Date:1995
Institutions:Medicine > Abteilung für Hämatologie und Internistische Onkologie
Identification Number:
ValueType
7669711PubMed ID
Classification:
NotationType
AdultMESH
AgedMESH
Antineoplastic Combined Chemotherapy Protocols/therapeutic useMESH
Colorectal Neoplasms/therapyMESH
Combined Modality TherapyMESH
FemaleMESH
Fluorouracil/adverse effectsMESH
GermanyMESH
HumansMESH
Infusions, IntravenousMESH
Interferon Alfa-2b/therapeutic useMESH
Leucovorin/adverse effectsMESH
MaleMESH
Middle AgedMESH
Remission InductionMESH
Subjects:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Universitätsbibliothek Regensburg
Deposited On:14 Apr 2010 05:04
Last Modified:14 Apr 2010 05:04
Item ID:14296
Owner Only: item control page
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