Köhne, C. H. and Wilke, H. and Hecker, H. and Schöffski, P. and Käufer, C. and Rauschecker, H. and Andreesen, Reinhard and Ohl, U. and Lange, H. J. and Klaassen, U. (1995) Interferon-alpha does not improve the antineoplastic efficacy of high-dose infusional 5-fluorouracil plus folinic acid in advanced colorectal cancer. First results of a randomized multicenter study by the Association of Medical Oncology of the German Cancer Society (AIO). Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 6 (5), pp. 461-6.
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BACKGROUND: High-dose 5-FU given weekly as a 24-h infusion in combination with folinic acid (FA) has been associated with low toxicity and a high response rate. Interferon-alpha (IFN) either alone or in combination with FA has also improved treatment results by modulating 5-FU activity. We therefore initiated a randomized multicenter trial comparing the ability of FA or IFN to modulate infusional ...
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|Institutions:||Medicine > Abteilung für Hämatologie und Internistische Onkologie|
|Subjects:||600 Technology > 610 Medical sciences Medicine|
|Refereed:||Yes, this version has been refereed|
|Created at the University of Regensburg:||Yes|
|Deposited On:||14 Apr 2010 05:04|
|Last Modified:||14 Apr 2010 05:04|