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Adoptive immunotherapy with tumor-cytotoxic macrophages derived from recombinant human granulocyte-macrophage colony-stimulating factor (rhuGM-CSF) mobilized peripheral blood monocytes

Hennemann, B. and Rehm, A. and Kottke, A. and Meidenbauer, N. and Andreesen, Reinhard (1997) Adoptive immunotherapy with tumor-cytotoxic macrophages derived from recombinant human granulocyte-macrophage colony-stimulating factor (rhuGM-CSF) mobilized peripheral blood monocytes. Journal of immunotherapy (Hagerstown, Md. : 1997) 20 (5), pp. 365-71.

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Abstract

We examined the mobilization of blood monocytes (MO) with recombinant human granulocyte-macrophage colony-stimulating factor (rhuGM-CSF) with regard to the in vitro generation of MO-derived tumor-cytotoxic macrophages (MAC) for use in adoptive immunotherapy of cancer patients. Eleven patients with progressing metastatic cancer received interferon (IFN)-gamma activated tumor-cytotoxic MAC ...

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Item Type:Article
Date:1997
Institutions:Medicine > Abteilung für Hämatologie und Internistische Onkologie
Identification Number:
ValueType
9336743PubMed ID
Classification:
NotationType
AdultMESH
AgedMESH
Carcinoma, Renal Cell/therapyMESH
Cytotoxicity, ImmunologicMESH
Feasibility StudiesMESH
Granulocyte Macrophage Colony-Stimulating Factors, Recombinant/therapeutic useMESH
HumansMESH
Immunotherapy, Adoptive/methodsMESH
Kidney Neoplasms/therapyMESH
Leukocyte Count/drug effectsMESH
Macrophage ActivationMESH
Macrophages/transplantationMESH
Melanoma/therapyMESH
Middle AgedMESH
Subjects:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Universitätsbibliothek Regensburg
Deposited On:15 Apr 2010 05:40
Last Modified:15 Apr 2010 05:40
Item ID:14311
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