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Phase I trial of adoptive immunotherapy of cancer patients using monocyte-derived macrophages activated with interferon gamma and lipopolysaccharide

Hennemann, B. and Beckmann, G. and Eichelmann, A. and Rehm, A. and Andreesen, Reinhard (1998) Phase I trial of adoptive immunotherapy of cancer patients using monocyte-derived macrophages activated with interferon gamma and lipopolysaccharide. Cancer immunology, immunotherapy : CII 45 (5), pp. 250-6.

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Abstract

Cells of the monocyte/macrophage lineage have shown antitumor activity in vitro and in murine models after activation with interferon (IFN) gamma. In vitro data suggest an additional effect on macrophage antitumor activity when IFN gamma is combined with endotoxin (lipopolysaccharides; LPS). In this study we treated nine cancer patients with a total of 62 MAK infusion cycles with autologous ...

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Item Type:Article
Date:1998
Institutions:Medicine > Abteilung für Hämatologie und Internistische Onkologie
Identification Number:
ValueType
9439648PubMed ID
Classification:
NotationType
Antithrombins/metabolismMESH
Blood Component TransfusionMESH
Cytokines/bloodMESH
FemaleMESH
HumansMESH
Immunotherapy, AdoptiveMESH
Interferon-gamma/pharmacologyMESH
Lipopolysaccharides/pharmacologyMESH
Macrophage Activation/drug effectsMESH
Macrophages/immunologyMESH
MaleMESH
Middle AgedMESH
Monocytes/immunologyMESH
Neoplasms/therapyMESH
Thrombin/metabolismMESH
Subjects:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Universitätsbibliothek Regensburg
Deposited On:15 Apr 2010 05:39
Last Modified:15 Apr 2010 05:39
Item ID:14315
Owner Only: item control page
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