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CD137 (ILA/4-1BB), a member of the TNF receptor family, induces monocyte activation via bidirectional signaling

Langstein, J. and Michel, J. and Fritsche, J. and Kreutz, M. and Andreesen, Reinhard and Schwarz, H. (1998) CD137 (ILA/4-1BB), a member of the TNF receptor family, induces monocyte activation via bidirectional signaling. Journal of immunology (Baltimore, Md. : 1950) 160 (5), pp. 2488-94.

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Abstract

CD137 (ILA/4-1BB), a member of the TNF receptor family, was shown previously to inhibit proliferation and to induce apoptosis in T lymphocytes. In this study, we identify CD137 as a novel and potent monocyte activation factor. CD137 protein induces expression of IL-6, IL-8, and TNF-alpha, and inhibits expression of IL-10. Furthermore, CD137 differentially regulates expression of cell surface ...

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Item Type:Article
Date:1998
Institutions:Medicine > Abteilung für Hämatologie und Internistische Onkologie
Identification Number:
ValueType
9498794PubMed ID
Classification:
NotationType
Antigens, CDMESH
Antigens, CD137MESH
Binding, Competitive/immunologyMESH
Cell Adhesion/immunologyMESH
Cells, CulturedMESH
Down-Regulation/immunologyMESH
Gene Expression RegulationMESH
HumansMESH
Interleukin-6/biosynthesisMESH
Interleukin-8/geneticsMESH
Monocytes/metabolismMESH
Polymerase Chain Reaction/methodsMESH
Receptors, IgG/biosynthesisMESH
Receptors, Nerve Growth Factor/physiologyMESH
Receptors, Tumor Necrosis Factor/physiologyMESH
Signal Transduction/immunologyMESH
Tumor Necrosis Factor-alpha/biosynthesisMESH
Subjects:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Universitätsbibliothek Regensburg
Deposited On:15 Apr 2010 05:37
Last Modified:15 Apr 2010 05:37
Item ID:14318
Owner Only: item control page
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