Köhne, C. H. and Schöffski, P. and Wilke, H. and Käufer, C. and Andreesen, Reinhard and Ohl, U. and Klaasen, U. and Westerhausen, M. and Hiddemann, W. and Schott, G. and Harstick, A. and Bade, J. and Horster, A. and Schubert, U. and Hecker, H. and Dörken, B. and Schmoll, H. J. (1998) Effective biomodulation by leucovorin of high-dose infusion fluorouracil given as a weekly 24-hour infusion: results of a randomized trial in patients with advanced colorectal cancer. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 16 (2), pp. 418-26.
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PURPOSE: To determine whether high-dose infusional fluorouracil (FU) is effectively modulated by leucovorin (LV), interferon (IFN) alpha-2b, or both when given to patients with metastatic colorectal cancer. PATIENTS AND METHODS: Patients (n = 236) with progressive, measurable disease were randomized to three groups and received FU 2,600 mg/m2 as a 24-hour continuous infusion (CI) weekly for 6 ...
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|Institutions:||Medicine > Abteilung für Hämatologie und Internistische Onkologie|
|Subjects:||600 Technology > 610 Medical sciences Medicine|
|Refereed:||Yes, this version has been refereed|
|Created at the University of Regensburg:||Yes|
|Deposited On:||15 Apr 2010 05:34|
|Last Modified:||15 Apr 2010 05:34|