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Effect of granulocyte-macrophage colony-stimulating factor treatment on phenotype, cytokine release and cytotoxicity of circulating blood monocytes and monocyte-derived macrophages

Hennemann, B. and Kreutz, M. and Rehm, A. and Andreesen, Reinhard (1998) Effect of granulocyte-macrophage colony-stimulating factor treatment on phenotype, cytokine release and cytotoxicity of circulating blood monocytes and monocyte-derived macrophages. British journal of haematology 102 (5), pp. 1197-203.

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Abstract

We studied phenotype, function and differentiation of mononuclear phagocytes in 11 cancer patients treated subcutaneously with 10O microg/kg recombinant human (rhu) GM-CSF for 7 d. The rhuGM-CSF treatment induced (1) a 5.9-fold increase in the number of blood monocytes (MO), (2) a decrease of CD14bright/CD16bright cells with a diminution of the mean fluorescence intensity (MFI) of CD14, and (3) a ...

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Item Type:Article
Date:1998
Institutions:Medicine > Abteilung für Hämatologie und Internistische Onkologie
Identification Number:
ValueType
9753045PubMed ID
Classification:
NotationType
AdultMESH
AgedMESH
Carcinoma, Renal Cell/therapyMESH
Cell DifferentiationMESH
Cytokines/metabolismMESH
Cytotoxicity, ImmunologicMESH
Granulocyte-Macrophage Colony-Stimulating Factor/therapeutic useMESH
HumansMESH
ImmunophenotypingMESH
Kidney Neoplasms/therapyMESH
Macrophages/pathologyMESH
Melanoma/pathologyMESH
Middle AgedMESH
Monocytes/pathologyMESH
Neopterin/metabolismMESH
Subjects:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Universitätsbibliothek Regensburg
Deposited On:15 Apr 2010 05:30
Last Modified:15 Apr 2010 05:30
Item ID:14330
Owner Only: item control page
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