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Reverse signaling through transmembrane TNF confers resistance to lipopolysaccharide in human monocytes and macrophages

Eissner, G. and Kirchner, S. and Lindner, H. and Kolch, W. and Janosch, P. and Grell, M. and Scheurich, P. and Andreesen, Reinhard and Holler, E. (2000) Reverse signaling through transmembrane TNF confers resistance to lipopolysaccharide in human monocytes and macrophages. Journal of immunology (Baltimore, Md. : 1950) 164 (12), pp. 6193-8.

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Abstract

We have previously reported that the CD14+ monocytic subpopulation of human PBMC induces programmed cell death (apoptosis) in cocultured endothelial cells (EC) when stimulated by bacterial endotoxin (LPS). Apoptosis is mediated by two routes, first via transmembrane TNF-alpha (mTNF) expressed on PBMC and, in addition, by TNF-independent soluble factors that trigger apoptosis in EC. Neutralizing ...

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Item Type:Article
Date:2000
Institutions:Medicine > Abteilung für Hämatologie und Internistische Onkologie
Identification Number:
ValueType
10843670PubMed ID
Classification:
NotationType
Antibodies, Monoclonal/pharmacologyMESH
Antigens, CD/physiologyMESH
Apoptosis/immunologyMESH
Cell Death/immunologyMESH
Cell LineMESH
Cell-Free System/immunologyMESH
Endothelium, Vascular/immunologyMESH
HumansMESH
Immunity, InnateMESH
Immunoglobulin Fab Fragments/pharmacologyMESH
Interleukin-1/secretionMESH
Interleukin-10/secretionMESH
Interleukin-6/secretionMESH
Lipopolysaccharides/immunologyMESH
Macrophages/secretionMESH
Membrane Proteins/immunologyMESH
Monocytes/secretionMESH
Receptors, Tumor Necrosis Factor/physiologyMESH
Receptors, Tumor Necrosis Factor, Type IMESH
Receptors, Tumor Necrosis Factor, Type IIMESH
Signal Transduction/immunologyMESH
SolubilityMESH
Tumor Necrosis Factor-alpha/secretionMESH
Subjects:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Universitätsbibliothek Regensburg
Deposited On:15 Apr 2010 05:23
Last Modified:15 Apr 2010 05:23
Item ID:14338
Owner Only: item control page
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