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Hsp70 plasma membrane expression on primary tumor biopsy material and bone marrow of leukemic patients

Hantschel, M. and Pfister, K. and Jordan, A. and Scholz, R. and Andreesen, Reinhard and Schmitz, G. and Schmetzer, H. and Hiddemann, W. and Multhoff, G. (2000) Hsp70 plasma membrane expression on primary tumor biopsy material and bone marrow of leukemic patients. Cell stress & chaperones 5 (5), pp. 438-42.

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A tumor-selective cell surface localization of heat shock protein 70 (Hsp70), the major heat-inducible member of the Hsp70 group, correlates with an increased sensitivity to lysis mediated by human natural killer (NK) cells and, therefore, might be of clinical relevance. With the exception of mammary carcinomas, an Hsp70 plasma membrane expression was found on freshly isolated human biopsy ...


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Item Type:Article
Institutions:Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie)
Identification Number:
8402925PubMed ID
Bone Marrow/pathologyMESH
Brain Neoplasms/pathologyMESH
Cell Membrane/metabolismMESH
Colorectal Neoplasms/pathologyMESH
HSP70 Heat-Shock Proteins/immunologyMESH
Histocompatibility Antigens Class I/metabolismMESH
Killer Cells, Natural/metabolismMESH
Leukemia, Myeloid, Acute/pathologyMESH
Liver Neoplasms/secondaryMESH
Lung Neoplasms/pathologyMESH
Neoplasms, Neuroepithelial/pathologyMESH
Pancreatic Neoplasms/pathologyMESH
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Deposited On:15 Apr 2010 05:22
Last Modified:15 Apr 2010 05:22
Item ID:14342
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