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Prognostic significance of increased IL-10 production in patients prior to allogeneic bone marrow transplantation

Holler, E. and Roncarolo, M. G. and Hintermeier-Knabe, R. and Eissner, G. and Ertl, B. and Schulz, U. and Knabe, H. and Kolb, H. J. and Andreesen, Reinhard and Wilmanns, W. (2000) Prognostic significance of increased IL-10 production in patients prior to allogeneic bone marrow transplantation. Bone marrow transplantation 25 (3), pp. 237-41.

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Abstract

IL-10 is a potent immunosuppressant which inhibits allo-antigen-specific T cell responses. In addition, IL-10 is a strong endogenous anti-inflammatory cytokine. To investigate the role of IL-10 in the induction of acute GVHD following allogeneic bone marrow transplantation (BMT) we performed a prospective study on spontaneous IL-10 production by peripheral blood mononuclear cells (PBMNC) in 84 ...

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Item Type:Article
Date:2000
Institutions:Medicine > Abteilung für Hämatologie und Internistische Onkologie
Identification Number:
ValueType
10673693PubMed ID
10.1038/sj.bmt.1702126DOI
Classification:
NotationType
AdolescentMESH
AdultMESH
Bone Marrow TransplantationMESH
Cell Culture TechniquesMESH
FemaleMESH
Graft vs Host Disease/etiologyMESH
HumansMESH
Interleukin-10/pharmacologyMESH
Leukemia/therapyMESH
Leukocytes, Mononuclear/metabolismMESH
MaleMESH
Middle AgedMESH
PrognosisMESH
Prospective StudiesMESH
Time FactorsMESH
Transplantation, HomologousMESH
Subjects:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Universitätsbibliothek Regensburg
Deposited On:15 Apr 2010 05:21
Last Modified:15 Apr 2010 05:21
Item ID:14344
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