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Comparative analysis of CD137 and LPS effects on monocyte activation, survival, and proliferation

Langstein, J. and Becke, F. M. and Söllner, L. and Krause, G. and Brockhoff, G. and Kreutz, M. and Andreesen, Reinhard and Schwarz, H. (2000) Comparative analysis of CD137 and LPS effects on monocyte activation, survival, and proliferation. Biochemical and biophysical research communications 273 (1), pp. 117-22.

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CD137 (ILA/4-1BB), a member of the TNF receptor family, regulates activation, survival and proliferation of primary human monocytes. Here we compare the activities of lipopolysaccharide (LPS), a classical and potent monocyte activator to that of CD137. LPS is a more potent activator of monocytes, as evidenced by a stronger induction of the proinflammatory cytokine IL-8. However, CD137 could ...


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Item type:Article
Institutions:Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie)
Identification Number:
10873573PubMed ID
Antigens, CDMESH
Antigens, CD137MESH
Apoptosis/drug effectsMESH
Cell Adhesion/drug effectsMESH
Cell Division/drug effectsMESH
Cell Survival/drug effectsMESH
Cells, CulturedMESH
Gene Expression Regulation/drug effectsMESH
Genes, myc/geneticsMESH
Macrophage Activation/drug effectsMESH
Macrophage Colony-Stimulating Factor/metabolismMESH
RNA, Messenger/metabolismMESH
Receptors, Nerve Growth Factor/metabolismMESH
Receptors, Tumor Necrosis Factor/metabolismMESH
Recombinant Fusion Proteins/metabolismMESH
Signal Transduction/drug effectsMESH
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Deposited on:15 Apr 2010 05:17
Last modified:15 Apr 2010 05:17
Item ID:14350
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