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Fludarabine induces apoptosis, activation, and allogenicity in human endothelial and epithelial cells: protective effect of defibrotide

Eissner, Günther and Multhoff, Gabriele and Gerbitz, Armin and Kirchner, Silvia and Bauer, Sonja and Haffner, Silvia and Sondermann, Daniela and Andreesen, Reinhard and Holler, Ernst (2002) Fludarabine induces apoptosis, activation, and allogenicity in human endothelial and epithelial cells: protective effect of defibrotide. Blood 100 (1), pp. 334-40.

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Abstract

Fludarabine is a nonmyeloablative immunosuppressant increasingly used as a component of alternative conditioning regimens before allogeneic bone marrow transplantation. It is expected to reduce conditioning-related toxicity and proinflammatory activation of the host tissues. However, in our in vitro study, we provide evidence that 2-fluoroadenine 9-beta-D-arabinofuranoside (F-Ara) as the active ...

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Item Type:Article
Date:2002
Institutions:Medicine > Abteilung für Hämatologie und Internistische Onkologie
Identification Number:
ValueType
12070045PubMed ID
Classification:
NotationType
Apoptosis/drug effectsMESH
Cytotoxicity Tests, ImmunologicMESH
Drug InteractionsMESH
Endothelium, Vascular/metabolismMESH
Epithelial Cells/metabolismMESH
HumansMESH
Immunity/drug effectsMESH
Intercellular Adhesion Molecule-1/metabolismMESH
Leukocytes/immunologyMESH
Polydeoxyribonucleotides/pharmacologyMESH
Protective Agents/pharmacologyMESH
Tumor Cells, Cultured/drug effectsMESH
Vidarabine/pharmacologyMESH
Subjects:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Universitätsbibliothek Regensburg
Deposited On:15 Apr 2010 05:16
Last Modified:15 Apr 2010 05:16
Item ID:14356
Owner Only: item control page
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