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Monocyte differentiation in intestine-like macrophage phenotype induced by epithelial cells

Spöttl, T. and Hausmann, M. and Kreutz, M. and Peuker, A. and Vogl, D. and Schölmerich, J. and Falkenstein, W. and Andreesen, Reinhard and Andus, T. and Herfarth, H. and Rogler, G. (2001) Monocyte differentiation in intestine-like macrophage phenotype induced by epithelial cells. Journal of leukocyte biology 70 (2), pp. 241-51.

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Abstract

Macrophages in normal colonic mucosa show a specific and distinct phenotype with low expression of the typical monocyte/macrophage surface antigens CD14, CD16, and CD11b and T-cell costimulatory molecules. A method for the in vitro induction of a macrophage phenotype similar to this intestinal phenotype is presented. Multicellular spheroids (MCSs) of intestinal epithelial cell (IEC) and control ...

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Item Type:Article
Date:2001
Institutions:Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie)
Identification Number:
ValueType
11493616PubMed ID
Classification:
NotationType
Antigens, CD/metabolismMESH
Cell CommunicationMESH
Cell Culture Techniques/methodsMESH
Cell DifferentiationMESH
Coculture TechniquesMESH
Epithelial Cells/cytologyMESH
Extracellular MatrixMESH
HumansMESH
ImmunophenotypingMESH
Interleukin-1/geneticsMESH
Intestines/cytologyMESH
Macrophages/cytologyMESH
Monocytes/cytologyMESH
RNA, Messenger/metabolismMESH
Time FactorsMESH
Tumor Cells, CulturedMESH
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Deposited On:20 Apr 2010 06:21
Last Modified:20 Apr 2010 06:21
Item ID:14387
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