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Is first-line single-agent mitoxantrone in the treatment of high-risk metastatic breast cancer patients as effective as combination chemotherapy? No difference in survival but higher quality of life were found in a multicenter randomized trial

Heidemann, E. and Stoeger, H. and Souchon, R. and Hirschmann, W.-D. and Bodenstein, H. and Oberhoff, C. and Fischer, J. T. and Schulze, M. and Clemens, M. and Andreesen, Reinhard and Mahlke, M. and König, M. and Scharl, A. and Fehnle, K. and Kaufmann, M. (2002) Is first-line single-agent mitoxantrone in the treatment of high-risk metastatic breast cancer patients as effective as combination chemotherapy? No difference in survival but higher quality of life were found in a multicenter randomized trial. Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 13 (11), pp. 1717-29.

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Abstract

BACKGROUND: To determine whether patients with high-risk metastatic breast cancer draw benefit from combination chemotherapy as first-line treatment. PATIENTS AND METHODS: A total of 260 women with measurable metastatic breast cancer fulfilling high-risk criteria, previously untreated with chemotherapy for their metastatic disease, were randomized to receive either mitoxantrone 12 mg/m(2) or the ...

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Item Type:Article
Date:2002
Institutions:Medicine > Abteilung für Hämatologie und Internistische Onkologie
Identification Number:
ValueType
12419743PubMed ID
Classification:
NotationType
AdultMESH
AgedMESH
Antineoplastic Combined Chemotherapy Protocols/therapeutic useMESH
Biopsy, NeedleMESH
Bone Neoplasms/secondaryMESH
Breast Neoplasms/pathologyMESH
Cyclophosphamide/administration & dosageMESH
Disease-Free SurvivalMESH
Epirubicin/administration & dosageMESH
FemaleMESH
Fluorouracil/administration & dosageMESH
GermanyMESH
HumansMESH
Liver Neoplasms/secondaryMESH
Logistic ModelsMESH
Lung Neoplasms/secondaryMESH
Middle AgedMESH
Mitoxantrone/administration & dosageMESH
Neoplasm StagingMESH
ProbabilityMESH
Proportional Hazards ModelsMESH
Quality of LifeMESH
Risk AssessmentMESH
Sensitivity and SpecificityMESH
Statistics, NonparametricMESH
Survival AnalysisMESH
Treatment OutcomeMESH
Subjects:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Universitätsbibliothek Regensburg
Deposited On:20 Apr 2010 06:20
Last Modified:20 Apr 2010 06:20
Item ID:14412
Owner Only: item control page
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