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Identification of genes expressed in tumor-associated macrophages

Gottfried, Eva and Faust, Stefan and Fritsche, Jana and Kunz-Schughart, Leoni A. and Andreesen, Reinhard and Miyake, Kensuke and Kreutz, Marina (2003) Identification of genes expressed in tumor-associated macrophages. Immunobiology 207 (5), pp. 351-9.

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Abstract

Most malignant tumors contain so-called tumor-associated macrophages (TAM) as a major component of their leukocytic infiltrate. To investigate the impact of the tumor microenvironment on activation and differentiation of macrophages, we established a 3-dimensional model system by culturing human monocytes within multicellular tumor spheroids. After 7 days, monocyte-derived TAM were isolated and ...

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Item Type:Article
Date:2003
Institutions:Medicine > Abteilung für Hämatologie und Internistische Onkologie
Identification Number:
ValueType
14575150PubMed ID
Classification:
NotationType
Antigens, CD/metabolismMESH
Antigens, Surface/metabolismMESH
Cells, CulturedMESH
Dipeptidases/metabolismMESH
Gene Expression RegulationMESH
HumansMESH
Interleukin-6/secretionMESH
Macrophages/metabolismMESH
Metalloendopeptidases/metabolismMESH
Monocytes/immunologyMESH
Neoplasms/immunologyMESH
PhenotypeMESH
RNA, Messenger/metabolismMESH
Subjects:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Universitätsbibliothek Regensburg
Deposited On:20 Apr 2010 05:50
Last Modified:20 Apr 2010 05:50
Item ID:14415
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