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Transcriptional regulation of CHI3L1, a marker gene for late stages of macrophage differentiation

Rehli, Michael and Niller, Hans-Helmut and Ammon, Christoph and Langmann, Sabine and Schwarzfischer, Lucia and Andreesen, Reinhard and Krause, Stefan W (2003) Transcriptional regulation of CHI3L1, a marker gene for late stages of macrophage differentiation. The Journal of biological chemistry 278 (45), pp. 44058-67.

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Abstract

The protein product of the CHI3L1 gene, human cartilage 39-kDa glycoprotein (HC-gp39), is a tissue-restricted, chitin-binding lectin and member of glycosyl hydrolase family 18. In contrast to many other monocyte/macrophage markers, its expression is absent in monocytes and strongly induced during late stages of human macrophage differentiation. To gain insights into the molecular mechanisms ...

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Item Type:Article
Date:2003
Institutions:Medicine > Abteilung für Hämatologie und Internistische Onkologie
Identification Number:
ValueType
12933821PubMed ID
10.1074/jbc.M306792200DOI
Classification:
NotationType
AnimalsMESH
Base SequenceMESH
Binding SitesMESH
Cell Differentiation/geneticsMESH
Cell LineMESH
Cell Nucleus/chemistryMESH
Consensus SequenceMESH
DNA/metabolismMESH
DNA FootprintingMESH
Drosophila/geneticsMESH
Electrophoretic Mobility Shift AssayMESH
Gene DeletionMESH
Gene ExpressionMESH
Gene Expression Regulation/drug effectsMESH
Glycoproteins/geneticsMESH
HumansMESH
LectinsMESH
Macrophages/cytologyMESH
Molecular Sequence DataMESH
MutagenesisMESH
Promoter Regions, Genetic/geneticsMESH
Sp1 Transcription Factor/metabolismMESH
Tetradecanoylphorbol Acetate/pharmacologyMESH
Transcription Factors/metabolismMESH
Transcription, GeneticMESH
TransfectionMESH
Subjects:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Universitätsbibliothek Regensburg
Deposited On:20 Apr 2010 05:48
Last Modified:20 Apr 2010 05:48
Item ID:14418
Owner Only: item control page
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