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Hybrid cell vaccination in metastatic melanoma: clinical and immunologic results of a phase I/II study

Haenssle, Holger A. and Krause, Stefan W. and Emmert, Steffen and Zutt, Markus and Kretschmer, Lutz and Schmidberger, Heinz and Andreesen, Reinhard and Soruri, Afsaneh (2004) Hybrid cell vaccination in metastatic melanoma: clinical and immunologic results of a phase I/II study. Journal of immunotherapy (Hagerstown, Md. : 1997) 27 (2), pp. 147-55.

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Abstract

Hybrid cell vaccination with cell fusion products (CFPs) of autologous tumor cells and mature allogenic MHC II bearing dendritic cells has been described to induce cytotoxic T lymphocyte (CTL)-mediated immune responses. The aim of this study was to assess safety, antitumor activity, and immune responses of a CFP-vaccine in patients with disseminated malignant melanoma. In a phase I/II study, we ...

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Item Type:Article
Date:2004
Institutions:Medicine > Abteilung für Hämatologie und Internistische Onkologie
Identification Number:
ValueType
14770086PubMed ID
Classification:
NotationType
AdultMESH
AgedMESH
Cancer VaccinesMESH
Cell DivisionMESH
Cell Line, TumorMESH
Dendritic Cells/metabolismMESH
Disease ProgressionMESH
Enzyme-Linked Immunosorbent AssayMESH
FemaleMESH
HumansMESH
Hybrid CellsMESH
Immunotherapy/methodsMESH
In Situ Nick-End LabelingMESH
MaleMESH
Melanoma/therapyMESH
Middle AgedMESH
T-Lymphocytes/metabolismMESH
Time FactorsMESH
Subjects:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Universitätsbibliothek Regensburg
Deposited On:20 Apr 2010 05:43
Last Modified:20 Apr 2010 05:43
Item ID:14428
Owner Only: item control page
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