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Both donor and recipient NOD2/CARD15 mutations associate with transplant-related mortality and GvHD following allogeneic stem cell transplantation

Holler, Ernst and Rogler, Gerhard and Herfarth, Hans and Brenmoehl, Julia and Wild, Peter Johannes and Hahn, Joachim and Eissner, Günther and Schölmerich, Jürgen and Andreesen, Reinhard (2004) Both donor and recipient NOD2/CARD15 mutations associate with transplant-related mortality and GvHD following allogeneic stem cell transplantation. Blood 104 (3), pp. 889-94.

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Abstract

Single nucleotide polymorphisms (SNPs) of the NOD2/CARD15 gene resulting in a diminished nuclear factor-kappaB (NF-kappaB) response to bacterial cell wall products have been associated with an increased incidence of Crohn disease. To assess a possible contribution of NOD2/CARD15 mutations to graft-versus-host disease (GvHD) and complications following allogeneic stem cell transplantation, we ...

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Item Type:Article
Date:2004
Institutions:Medicine > Abteilung für Hämatologie und Internistische Onkologie
Identification Number:
ValueType
15090455PubMed ID
10.1182/blood-2003-10-3543DOI
Classification:
NotationType
AdolescentMESH
AdultMESH
AgedMESH
Carrier Proteins/geneticsMESH
DNA/isolation & purificationMESH
FemaleMESH
Graft vs Host Disease/geneticsMESH
HumansMESH
Intracellular Signaling Peptides and ProteinsMESH
MaleMESH
Middle AgedMESH
MutationMESH
Nod2 Signaling Adaptor ProteinMESH
Polymorphism, Single Nucleotide/geneticsMESH
Retrospective StudiesMESH
Stem Cell Transplantation/mortalityMESH
Survival AnalysisMESH
Time FactorsMESH
Transplantation, Homologous/mortalityMESH
Subjects:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Universitätsbibliothek Regensburg
Deposited On:20 Apr 2010 05:40
Last Modified:20 Apr 2010 05:40
Item ID:14430
Owner Only: item control page
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