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LPS resistance in monocytic cells caused by reverse signaling through transmembrane TNF (mTNF) is mediated by the MAPK/ERK pathway

Kirchner, Silvia and Boldt, Simone and Kolch, Walter and Haffner, Silvia and Kazak, Seran and Janosch, Petra and Holler, Ernst and Andreesen, Reinhard and Eissner, Günther (2004) LPS resistance in monocytic cells caused by reverse signaling through transmembrane TNF (mTNF) is mediated by the MAPK/ERK pathway. Journal of leukocyte biology 75 (2), pp. 324-31.

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Abstract

The transmembrane form of tumor necrosis factor (mTNF), expressed on activated monocytes (MO) and macrophages (MPhi), is able to induce apoptosis in human endothelial cells (EC). Apoptosis is mediated by two distinct mechanisms: direct cell contact and a yet-unidentified soluble protein, death factor X. In addition, mTNF acts as a receptor that transduces a "reverse signal" into MO/MPhi when ...

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Item Type:Article
Date:2004
Institutions:Medicine > Abteilung für Hämatologie und Internistische Onkologie
Identification Number:
ValueType
14612430PubMed ID
10.1189/jlb.0703343DOI
Classification:
NotationType
Cell LineMESH
Cytokines/biosynthesisMESH
HumansMESH
Lipopolysaccharides/pharmacologyMESH
MAP Kinase Signaling System/physiologyMESH
Macrophages/physiologyMESH
Membrane Proteins/physiologyMESH
Mitogen-Activated Protein Kinase Kinases/metabolismMESH
Mitogen-Activated Protein Kinases/metabolismMESH
Monocytes/physiologyMESH
Protein Kinase C/antagonists & inhibitorsMESH
Signal TransductionMESH
Tumor Necrosis Factor-alpha/physiologyMESH
Subjects:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Universitätsbibliothek Regensburg
Deposited On:20 Apr 2010 05:41
Last Modified:20 Apr 2010 05:41
Item ID:14432
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