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Effect of different tumor necrosis factor (TNF) reactive agents on reverse signaling of membrane integrated TNF in monocytes

Kirchner, Silvia and Holler, Ernst and Haffner, Silvia and Andreesen, Reinhard and Eissner, Günther (2004) Effect of different tumor necrosis factor (TNF) reactive agents on reverse signaling of membrane integrated TNF in monocytes. Cytokine 28 (2), pp. 67-74.

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Abstract

Reverse signaling of transmembrane TNF (mTNF) contributes to the versatility of this cytokine superfamily. Previously, we could demonstrate that mTNF acting as receptor confers resistance to bacterial lipopolysaccharide in monocytes and macrophages (MO/MPhi). Reverse signaling can be induced by incubation with the monoclonal anti-TNF antibody 195F and other TNF antagonists, such as the humanized ...

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Item Type:Article
Date:2004
Institutions:Medicine > Abteilung für Hämatologie und Internistische Onkologie
Identification Number:
ValueType
15381183PubMed ID
10.1016/j.cyto.2004.06.008DOI
Classification:
NotationType
Apoptosis/drug effectsMESH
Cell LineMESH
Cell Membrane/metabolismMESH
Cells, CulturedMESH
Lipopolysaccharides/pharmacologyMESH
MAP Kinase Signaling System/drug effectsMESH
Membrane Proteins/metabolismMESH
Monocytes/metabolismMESH
Signal Transduction/drug effectsMESH
SolubilityMESH
Tumor Necrosis Factors/metabolismMESH
Subjects:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Universitätsbibliothek Regensburg
Deposited On:20 Apr 2010 05:32
Last Modified:20 Apr 2010 05:32
Item ID:14433
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