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Treatment of colon and lung cancer patients with ex vivo heat shock protein 70-peptide-activated, autologous natural killer cells: a clinical phase i trial.

Krause, Stefan W and Gastpar, Robert and Andreesen, Reinhard and Gross, Catharina and Ullrich, Heidrun and Thonigs, Gerald and Pfister, Karin and Multhoff, Gabriele (2004) Treatment of colon and lung cancer patients with ex vivo heat shock protein 70-peptide-activated, autologous natural killer cells: a clinical phase i trial. Clinical cancer research : an official journal of the American Association for Cancer Research 10 (11), pp. 3699-707.

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Abstract

PURPOSE: The 14 amino acid sequence (aa(450-463)) TKDNNLLGRFELSG (TKD) of heat shock protein 70 (Hsp70) was identified as a tumor-selective recognition structure for natural killer (NK) cells. Incubation of peripheral blood lymphocyte cells with TKD plus low-dose interleukin 2 (IL-2) enhances the cytolytic activity of NK cells against Hsp70 membrane-positive tumors, in vitro and in vivo. These ...

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Item Type:Article
Date:2004
Institutions:Medicine > Abteilung für Hämatologie und Internistische Onkologie
Identification Number:
ValueType
15585648PubMed ID
10.1158/1078-0432.CCR-03-0683DOI
Classification:
NotationType
AdultMESH
AgedMESH
Antigens, CD/biosynthesisMESH
Cell Membrane/metabolismMESH
Cell MovementMESH
Colonic Neoplasms/therapyMESH
Cytotoxicity, ImmunologicMESH
Disease ProgressionMESH
FemaleMESH
Follow-Up StudiesMESH
GranzymesMESH
HSP70 Heat-Shock Proteins/chemistryMESH
HumansMESH
Interferon-gamma/bloodMESH
Interleukin-2/chemistryMESH
Killer Cells, Natural/cytologyMESH
Lectins, C-Type/biosynthesisMESH
Lung Neoplasms/therapyMESH
MaleMESH
Middle AgedMESH
NK Cell Lectin-Like Receptor Subfamily DMESH
Neoplasm MetastasisMESH
PhenotypeMESH
Serine Endopeptidases/bloodMESH
Time FactorsMESH
Treatment OutcomeMESH
Tumor Necrosis Factor-alpha/biosynthesisMESH
Subjects:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Universitätsbibliothek Regensburg
Deposited On:20 Apr 2010 05:40
Last Modified:20 Apr 2010 05:40
Item ID:14434
Owner Only: item control page
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