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Pioglitazone and rofecoxib combined with angiostatically scheduled trofosfamide in the treatment of far-advanced melanoma and soft tissue sarcoma

Reichle, Albrecht and Bross, Klaus and Vogt, Thomas and Bataille, Frauke and Wild, Peter and Berand, Anna and Krause, Stefan W. and Andreesen, Reinhard (2004) Pioglitazone and rofecoxib combined with angiostatically scheduled trofosfamide in the treatment of far-advanced melanoma and soft tissue sarcoma. Cancer 101 (10), pp. 2247-56.

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Abstract

BACKGROUND: Combined treatment approaches targeting tumor cells as well as stromal cells may control chemorefractory malignancies. In the current study, the authors sought to test one such combined approach in the treatment of chemorefractory melanoma and soft tissue sarcoma. METHODS: A Phase II trial was initiated to analyze the activity of a continuously administered molecularly targeted ...

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Item Type:Article
Date:2004
Institutions:Medicine > Abteilung für Hämatologie und Internistische Onkologie
Identification Number:
ValueType
15470711PubMed ID
10.1002/cncr.20574DOI
Classification:
NotationType
Administration, OralMESH
AdultMESH
AgedMESH
Antineoplastic Agents, Alkylating/adverse effectsMESH
Antineoplastic Combined Chemotherapy Protocols/therapeutic useMESH
C-Reactive Protein/drug effectsMESH
Cyclophosphamide/analogs & derivativesMESH
FemaleMESH
HumansMESH
Hypoglycemic Agents/adverse effectsMESH
Lactones/adverse effectsMESH
MaleMESH
Melanoma/pathologyMESH
Middle AgedMESH
Sarcoma/drug therapyMESH
SulfonesMESH
Thiazolidinediones/adverse effectsMESH
Treatment OutcomeMESH
Tumor Markers, Biological/analysisMESH
Subjects:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Universitätsbibliothek Regensburg
Deposited On:20 Apr 2010 05:23
Last Modified:20 Apr 2010 05:23
Item ID:14439
Owner Only: item control page
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