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Oligotide, a defibrotide derivative, protects human microvascular endothelial cells against fludarabine-induced activation, damage and allogenicity

Eissner, G. and Iacobelli, M. and Blüml, S. and Burger, V. and Haffner, S. and Andreesen, Reinhard and Holler, E. (2005) Oligotide, a defibrotide derivative, protects human microvascular endothelial cells against fludarabine-induced activation, damage and allogenicity. Bone marrow transplantation 35 (9), pp. 915-20.

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Abstract

Fludarabine is a nonmyeloablative immunosuppressant increasingly used as a component of alternative reduced-intensity conditioning regimens prior to allogeneic stem cell transplantation (SCT). However, we have previously shown that 2-fluoroadenine 9-beta-D-arabinofuranoside (F-Ara) as the active metabolized form of fludarabine induces damage, activation and allogenicity in human microvascular ...

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Item Type:Article
Date:2005
Institutions:Medicine > Abteilung für Hämatologie und Internistische Onkologie
Identification Number:
ValueType
15778728PubMed ID
10.1038/sj.bmt.1704930DOI
Classification:
NotationType
Antineoplastic Agents/toxicityMESH
Cell LineMESH
Cell Movement/drug effectsMESH
Endothelial Cells/metabolismMESH
Endothelium, Vascular/physiopathologyMESH
Oligodeoxyribonucleotides/administration & dosageMESH
PolydeoxyribonucleotidesMESH
Transplantation Conditioning/methodsMESH
Vascular Diseases/prevention & controlMESH
Vidarabine/toxicityMESH
Subjects:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Universitätsbibliothek Regensburg
Deposited On:20 Apr 2010 05:24
Last Modified:20 Apr 2010 05:24
Item ID:14441
Owner Only: item control page
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