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Expression of heme oxygenase-1 protects endothelial cells from irradiation-induced apoptosis

Ewing, P. and Wilke, A. and Eissner, G. and Holler, E. and Andreesen, Reinhard and Gerbitz, A. (2005) Expression of heme oxygenase-1 protects endothelial cells from irradiation-induced apoptosis. Endothelium : journal of endothelial cell research 12 (3), pp. 113-9.

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Abstract

A common side effect of therapeutic use of ionizing irradiation is endothelial cell damage resulting in a variety of clinical complications. Thus, preservation of endothelial function after irradiation could potentially limit toxicity. Using the murine endothelioma cell line bEnd2 we show here that induction of heme oxygenase-1 (HO-1) by cobalt protoporphyrine IX (CoPP) inhibits ...

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Item Type:Article
Date:2005
Institutions:Medicine > Abteilung für Hämatologie und Internistische Onkologie
Identification Number:
ValueType
16291514PubMed ID
10.1080/10623320500189814DOI
Classification:
NotationType
AnimalsMESH
Apoptosis/radiation effectsMESH
Cell LineMESH
Cytochromes c/metabolismMESH
Endothelial Cells/enzymologyMESH
Enzyme Activation/radiation effectsMESH
Heme Oxygenase-1/metabolismMESH
Metalloporphyrins/pharmacologyMESH
MiceMESH
Radiotherapy/adverse effectsMESH
X-RaysMESH
Subjects:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Universitätsbibliothek Regensburg
Deposited On:20 Apr 2010 05:21
Last Modified:20 Apr 2010 06:57
Item ID:14442
Owner Only: item control page
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