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Isolation and characterization of human antigen-specific TCR alpha beta+ CD4(-)CD8- double-negative regulatory T cells

Fischer, Karin and Voelkl, Simon and Heymann, Jana and Przybylski, Grzegorz K. and Mondal, Krishna and Laumer, Monika and Kunz-Schughart, Leoni and Schmidt, Christian A. and Andreesen, Reinhard and Mackensen, Andreas (2005) Isolation and characterization of human antigen-specific TCR alpha beta+ CD4(-)CD8- double-negative regulatory T cells. Blood 105 (7), pp. 2828-35.

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Abstract

Down-regulation of immune responses by regulatory T (Treg) cells is an important mechanism involved in the induction of tolerance to allo-antigens (Ags). Recently, a novel subset of Ag-specific T-cell receptor (TCR)alpha beta+ CD4(-)CD8- (double-negative [DN]) Treg cells has been found to be able to prevent the rejection of skin and heart allografts by specifically inhibiting the function of ...

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Item Type:Article
Date:2005
Institutions:Medicine > Abteilung für Hämatologie und Internistische Onkologie
Identification Number:
ValueType
15572590PubMed ID
10.1182/blood-2004-07-2583DOI
Classification:
NotationType
Antigen-Presenting Cells/metabolismMESH
Antigens, CD3/metabolismMESH
Antigens, CD4/metabolismMESH
Antigens, CD8/metabolismMESH
Apoptosis/immunologyMESH
CD4-Positive T-Lymphocytes/metabolismMESH
CD8-Positive T-Lymphocytes/metabolismMESH
Cell Division/immunologyMESH
Flow CytometryMESH
HumansMESH
Immune Tolerance/immunologyMESH
Immunomagnetic SeparationMESH
ImmunophenotypingMESH
Receptors, Antigen, T-Cell, alpha-beta/metabolismMESH
Thymus Gland/cytologyMESH
Subjects:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Universitätsbibliothek Regensburg
Deposited On:20 Apr 2010 05:22
Last Modified:20 Apr 2010 05:22
Item ID:14443
Owner Only: item control page
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