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Transcription factor Tfec contributes to the IL-4-inducible expression of a small group of genes in mouse macrophages including the granulocyte colony-stimulating factor receptor

Rehli, Michael and Sulzbacher, Sabine and Pape, Sabine and Ravasi, Timothy and Wells, Christine A. and Heinz, Sven and Söllner, Liane and El Chartouni, Carol and Krause, Stefan W. and Steingrimsson, Eirikur and Hume, David A. and Andreesen, Reinhard (2005) Transcription factor Tfec contributes to the IL-4-inducible expression of a small group of genes in mouse macrophages including the granulocyte colony-stimulating factor receptor. Journal of immunology (Baltimore, Md. : 1950) 174 (11), pp. 7111-22.

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Abstract

Expression of the mouse transcription factor EC (Tfec) is restricted to the myeloid compartment, suggesting a function for Tfec in the development or function of these cells. However, mice lacking Tfec develop normally, indicating a redundant role for Tfec in myeloid cell development. We now report that Tfec is specifically induced in bone marrow-derived macrophages upon stimulation with the Th2 ...

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Item Type:Article
Date:2005
Institutions:Medicine > Abteilung für Hämatologie und Internistische Onkologie
Identification Number:
ValueType
15908341PubMed ID
Classification:
NotationType
AnimalsMESH
Base SequenceMESH
Basic Helix-Loop-Helix Leucine Zipper Transcription FactorsMESH
Bone Marrow Cells/metabolismMESH
Cell LineMESH
Cells, CulturedMESH
Gene Expression Profiling/methodsMESH
Helix-Loop-Helix Motifs/immunologyMESH
ImmunophenotypingMESH
Interleukin-4/physiologyMESH
Lipopolysaccharides/pharmacologyMESH
Macrophages/metabolismMESH
MiceMESH
Mice, Inbred BALB CMESH
Mice, KnockoutMESH
Molecular Sequence DataMESH
Oligonucleotide Array Sequence Analysis/methodsMESH
Receptors, Granulocyte Colony-Stimulating Factor/geneticsMESH
STAT6 Transcription FactorMESH
Signal Transduction/immunologyMESH
Trans-Activators/physiologyMESH
Transcription Factors/physiologyMESH
Up-Regulation/immunologyMESH
Subjects:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Universitätsbibliothek Regensburg
Deposited On:20 Apr 2010 05:15
Last Modified:20 Apr 2010 05:15
Item ID:14451
Owner Only: item control page
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