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Reverse signalling of membrane-integrated tumour necrosis factor differentially regulates alloresponses of CD4+ and CD8+ T cells against human microvascular endothelial cells

Vudattu, Nalini K and Holler, Ernst and Ewing, Patricia and Schulz, Ute and Haffner, Silvia and Burger, Verena and Kirchner, Silvia and Andreesen, Reinhard and Eissner, Günther (2005) Reverse signalling of membrane-integrated tumour necrosis factor differentially regulates alloresponses of CD4+ and CD8+ T cells against human microvascular endothelial cells. Immunology 115 (4), pp. 536-43.

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Abstract

Reverse signalling of membrane-integrated ligands is a common phenomenon in the tumour necrosis factor (TNF) family and contributes to the pleiotropy of this pro-inflammatory cytokine and to the plasticity of the immune system in general. Transmembrane TNF (mTNF) itself can induce resistance to bacterial endotoxin in monocytes and can stimulate the immune activity of mitogen-activated, as well as ...

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Item Type:Article
Date:2005
Institutions:Medicine > Abteilung für Hämatologie und Internistische Onkologie
Identification Number:
ValueType
12424195PubMed ID
10.1111/j.1365-2567.2005.02190.xDOI
Classification:
NotationType
CD4-Positive T-Lymphocytes/immunologyMESH
CD8-Positive T-Lymphocytes/immunologyMESH
Cell Division/immunologyMESH
Cell LineMESH
Cell Membrane/immunologyMESH
Cytotoxicity, Immunologic/immunologyMESH
Down-Regulation/immunologyMESH
Endothelial Cells/immunologyMESH
Endothelium, Vascular/immunologyMESH
HumansMESH
Leukocytes, Mononuclear/immunologyMESH
Lymphocyte Activation/immunologyMESH
Microcirculation/immunologyMESH
PhenotypeMESH
Receptors, Tumor Necrosis Factor/immunologyMESH
Signal Transduction/immunologyMESH
Th2 Cells/immunologyMESH
Tumor Necrosis Factor-alpha/immunologyMESH
Subjects:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Universitätsbibliothek Regensburg
Deposited On:20 Apr 2010 09:41
Last Modified:20 Apr 2010 09:41
Item ID:14473
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