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Antigen recognition induces phosphatidylserine exposure on the cell surface of human CD8+ T cells.

Fischer, Karin and Voelkl, Simon and Berger, Jana and Andreesen, Reinhard and Pomorski, Thomas and Mackensen, Andreas (2006) Antigen recognition induces phosphatidylserine exposure on the cell surface of human CD8+ T cells. Blood 108 (13), pp. 4094-101.

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Abstract

In eukaryotic cells the phospholipid phosphatidylserine (PS) is restricted to the inner plasma-membrane leaflet. This lipid asymmetry, which is maintained by the concerted action of phospholipid transport proteins, is mainly lost during apoptosis. Here, we demonstrate that primary human CD8+ cytotoxic T lymphocytes (CTLs) expose PS on T-cell receptor (TCR)-mediated antigen (Ag) recognition. In ...

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Item Type:Article
Date:2006
Institutions:Medicine > Abteilung für Hämatologie und Internistische Onkologie
Identification Number:
ValueType
16912227PubMed ID
10.1182/blood-2006-03-011742DOI
Classification:
NotationType
Annexin A5/immunologyMESH
Antigen Presentation/immunologyMESH
Antigens/immunologyMESH
Antigens, Neoplasm/immunologyMESH
Apoptosis/immunologyMESH
CD8-Positive T-Lymphocytes/immunologyMESH
Cell Communication/immunologyMESH
Cell LineMESH
Cytokines/immunologyMESH
HumansMESH
Lymphocyte Activation/immunologyMESH
Membrane Microdomains/immunologyMESH
Neoplasm Proteins/immunologyMESH
Phosphatidylserines/immunologyMESH
Protein Transport/immunologyMESH
Receptors, Antigen, T-Cell/immunologyMESH
Subjects:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Universitätsbibliothek Regensburg
Deposited On:20 Apr 2010 09:38
Last Modified:20 Apr 2010 09:38
Item ID:14481
Owner Only: item control page
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