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Genome-wide profiling of CpG methylation identifies novel targets of aberrant hypermethylation in myeloid leukemia

Gebhard, Claudia and Schwarzfischer, Lucia and Pham, Thu-Hang and Schilling, Elmar and Klug, Maja and Andreesen, Reinhard and Rehli, Michael (2006) Genome-wide profiling of CpG methylation identifies novel targets of aberrant hypermethylation in myeloid leukemia. Cancer research 66 (12), pp. 6118-28.

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Abstract

The methylation of CpG islands is associated with transcriptional repression and, in cancer, leads to the abnormal silencing of tumor suppressor genes. Because aberrant hypermethylation may be used as a marker for disease, a sensitive method for the global detection of DNA methylation events is of particular importance. We describe a novel and robust technique, called methyl-CpG ...

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Item Type:Article
Date:2006
Institutions:Medicine > Abteilung für Hämatologie und Internistische Onkologie
Identification Number:
ValueType
16778185PubMed ID
10.1158/0008-5472.CAN-06-0376DOI
Classification:
NotationType
Acute DiseaseMESH
Cell Line, TumorMESH
CpG Islands/geneticsMESH
DNA MethylationMESH
DNA, Neoplasm/metabolismMESH
Gene Expression ProfilingMESH
Genome, HumanMESH
HumansMESH
Immunoglobulin Fragments/immunologyMESH
Immunoprecipitation/methodsMESH
Leukemia, Myeloid/metabolismMESH
Oligonucleotide Array Sequence AnalysisMESH
Polymerase Chain ReactionMESH
Promoter Regions, GeneticMESH
RNA, Messenger/geneticsMESH
Recombinant Fusion Proteins/immunologyMESH
Reproducibility of ResultsMESH
U937 CellsMESH
Subjects:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Universitätsbibliothek Regensburg
Deposited On:20 Apr 2010 09:39
Last Modified:20 Apr 2010 09:39
Item ID:14482
Owner Only: item control page
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