Gottfried, Eva and Rehli, Michael and Hahn, Joachim and Holler, Ernst and Andreesen, Reinhard and Kreutz, Marina (2006) Monocyte-derived cells express CYP27A1 and convert vitamin D3 into its active metabolite. Biochemical and biophysical research communications 349 (1), pp. 209-13.
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CYP27A1 catalyses hydroxylations in the biosynthesis of bile acids and the bioactivation of vitamin D3. We investigated the expression of CYP27A1 in human monocytes, monocyte-derived macrophages, and dendritic cells on mRNA and protein levels as well as its enzymatic activity in comparison with the expression of CYP27B1 and CYP24A1. Macrophages showed a strong expression of CYP27A1, whereas ...
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|Institutions:||Medicine > Abteilung für Hämatologie und Internistische Onkologie|
|Subjects:||600 Technology > 610 Medical sciences Medicine|
|Refereed:||Yes, this version has been refereed|
|Created at the University of Regensburg:||Yes|
|Deposited On:||20 Apr 2010 09:37|
|Last Modified:||20 Apr 2010 09:37|