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Monocyte-derived cells express CYP27A1 and convert vitamin D3 into its active metabolite

Gottfried, Eva and Rehli, Michael and Hahn, Joachim and Holler, Ernst and Andreesen, Reinhard and Kreutz, Marina (2006) Monocyte-derived cells express CYP27A1 and convert vitamin D3 into its active metabolite. Biochemical and biophysical research communications 349 (1), pp. 209-13.

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Abstract

CYP27A1 catalyses hydroxylations in the biosynthesis of bile acids and the bioactivation of vitamin D3. We investigated the expression of CYP27A1 in human monocytes, monocyte-derived macrophages, and dendritic cells on mRNA and protein levels as well as its enzymatic activity in comparison with the expression of CYP27B1 and CYP24A1. Macrophages showed a strong expression of CYP27A1, whereas ...

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Item Type:Article
Date:2006
Institutions:Medicine > Abteilung für Hämatologie und Internistische Onkologie
Identification Number:
ValueType
16930540PubMed ID
10.1016/j.bbrc.2006.08.034DOI
Classification:
NotationType
25-Hydroxyvitamin D3 1-alpha-Hydroxylase/metabolismMESH
Cell Line, TumorMESH
Cholecalciferol/metabolismMESH
Cytochrome P-450 CYP27A1MESH
Dendritic Cells/metabolismMESH
HumansMESH
Leukocytes, Mononuclear/metabolismMESH
Macrophages/metabolismMESH
Monocytes/metabolismMESH
RNA, Messenger/metabolismMESH
Steroid Hydroxylases/chemistryMESH
Subjects:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Universitätsbibliothek Regensburg
Deposited On:20 Apr 2010 09:37
Last Modified:20 Apr 2010 09:37
Item ID:14484
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