Hoffmann, Petra and Eder, Ruediger and Boeld, Tina J and Doser, Kristina and Piseshka, Biserka and Andreesen, Reinhard and Edinger, Matthias (2006) Only the CD45RA+ subpopulation of CD4+CD25high T cells gives rise to homogeneous regulatory T-cell lines upon in vitro expansion. Blood 108 (13), pp. 4260-7.
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Thymus-derived CD4+ CD25+ regulatory T cells suppress autoreactive CD4+ and CD8+ T cells and thereby protect from autoimmunity. In animal models, adoptive transfer of CD4+ CD25+ regulatory T cells has been shown to prevent and even cure autoimmune diseases as well as pathogenic alloresponses after solid organ and stem-cell transplantations. We recently described methods for the efficient in vitro ...
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|Institutions:||Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie)|
|Dewey Decimal Classification:||600 Technology > 610 Medical sciences Medicine|
|Refereed:||Yes, this version has been refereed|
|Created at the University of Regensburg:||Yes|
|Deposited on:||20 Apr 2010 09:37|
|Last modified:||20 Apr 2010 09:37|