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Phase I study of adoptive T-cell therapy using antigen-specific CD8+ T cells for the treatment of patients with metastatic melanoma

Mackensen, Andreas and Meidenbauer, Norbert and Vogl, Sandra and Laumer, Monika and Berger, Jana and Andreesen, Reinhard (2006) Phase I study of adoptive T-cell therapy using antigen-specific CD8+ T cells for the treatment of patients with metastatic melanoma. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 24 (31), pp. 5060-9.

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Abstract

PURPOSE: The adoptive transfer of in vitro generated tumor antigen-specific cytotoxic T lymphocytes (CTL) provides a promising approach to the immunotherapy of cancer. A phase I study was conducted to test the feasibility, safety, and survival of adoptively transferred Melan-A-specific CTL lines in melanoma patients. PATIENTS AND METHODS: Eleven HLA-A2+ patients with metastatic melanoma received ...

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Item Type:Article
Date:2006
Institutions:Medicine > Abteilung für Hämatologie und Internistische Onkologie
Identification Number:
ValueType
17075125PubMed ID
10.1200/JCO.2006.07.1100DOI
Classification:
NotationType
AdultMESH
AgedMESH
Antigens, Neoplasm/analysisMESH
CD8-Positive T-LymphocytesMESH
Feasibility StudiesMESH
FemaleMESH
Gene Expression Regulation, NeoplasticMESH
HumansMESH
ImmunohistochemistryMESH
Immunotherapy, Adoptive/methodsMESH
Lymph Nodes/radionuclide imagingMESH
Lymphatic MetastasisMESH
MaleMESH
Melanoma/therapyMESH
Middle AgedMESH
Neoplasm Proteins/analysisMESH
Positron-Emission TomographyMESH
Skin Neoplasms/therapyMESH
Survival AnalysisMESH
T-Lymphocytes, CytotoxicMESH
Tomography, X-Ray ComputedMESH
Treatment OutcomeMESH
Tumor Markers, Biological/analysisMESH
Subjects:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Universitätsbibliothek Regensburg
Deposited On:20 Apr 2010 09:36
Last Modified:20 Apr 2010 09:36
Item ID:14492
Owner Only: item control page
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