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Donor CD4+ T-cell production of tumor necrosis factor alpha significantly contributes to the early proinflammatory events of graft-versus-host disease

Ewing, Patricia and Miklos, Sandra and Olkiewicz, Krystyna M. and Müller, Gunnar and Andreesen, Reinhard and Holler, Ernst and Cooke, Kenneth R. and Hildebrandt, Gerhard C. (2007) Donor CD4+ T-cell production of tumor necrosis factor alpha significantly contributes to the early proinflammatory events of graft-versus-host disease. Experimental hematology 35 (1), pp. 155-63.

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Abstract

OBJECTIVE: Tumor necrosis factor alpha (TNFalpha) is an old foe in allogeneic bone marrow transplantation (allo-BMT) promoting acute graft-versus-host disease (aGVHD). We investigated to what extent donor T cells contribute to TNFalpha production. METHODS: Lethally irradiated B6D2F1 mice were transplanted with bone marrow (BM) and T cells from syngeneic B6D2F1 or allogeneic B6 donors and assessed ...

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Item Type:Article
Date:2007
Institutions:Medicine > Abteilung für Hämatologie und Internistische Onkologie
Identification Number:
ValueType
17198884PubMed ID
10.1016/j.exphem.2006.09.012DOI
Classification:
NotationType
AnimalsMESH
Bone Marrow Transplantation/adverse effectsMESH
CD4-Positive T-Lymphocytes/transplantationMESH
CD8-Positive T-LymphocytesMESH
Graft vs Host Disease/pathologyMESH
Inflammation/etiologyMESH
KineticsMESH
MiceMESH
Mice, Inbred StrainsMESH
Survival RateMESH
T-Lymphocytes/transplantationMESH
Tissue DonorsMESH
Transplantation, HomologousMESH
Transplantation, IsogeneicMESH
Tumor Necrosis Factor-alpha/physiologyMESH
Subjects:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Universitätsbibliothek Regensburg
Deposited On:20 Apr 2010 09:33
Last Modified:20 Apr 2010 09:33
Item ID:14497
Owner Only: item control page
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