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Cobalt protoporphyrine IX-mediated heme oxygenase-I induction alters the inflammatory cytokine response, but not antigen presentation after experimental allogeneic bone marrow transplantation

Ewing, Patricia and Hildebrandt, Gerhard C. and Planke, Simone and Andreesen, Reinhard and Holler, Ernst and Gerbitz, Armin (2007) Cobalt protoporphyrine IX-mediated heme oxygenase-I induction alters the inflammatory cytokine response, but not antigen presentation after experimental allogeneic bone marrow transplantation. International journal of molecular medicine 20 (3), pp. 301-8.

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Abstract

Acute graft-versus-host disease (aGvHD) remains the major cause of mortality after allogeneic stem cell transplantation. Acute GvHD can be partially prevented when heme oxygenase-1 (HO-1) is induced in the recipient prior to transplantation but the mechanisms are not fully understood. Using a murine haploidentical bone marrow transplantation (BMT) model (C57Bl/6 right curved arrow B6D2F1) we ...

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Item Type:Article
Date:2007
Institutions:Medicine > Abteilung für Hämatologie und Internistische Onkologie
Identification Number:
ValueType
17671733PubMed ID
Classification:
NotationType
Acute DiseaseMESH
AnimalsMESH
Antigen Presentation/drug effectsMESH
Bone Marrow Transplantation/immunologyMESH
Cytokines/biosynthesisMESH
Dendritic Cells/immunologyMESH
Enzyme Induction/drug effectsMESH
FemaleMESH
Graft vs Host Disease/prevention & controlMESH
Heme Oxygenase-1/biosynthesisMESH
Inflammation Mediators/metabolismMESH
Lymphocyte Activation/drug effectsMESH
Lymphocyte Culture Test, MixedMESH
MiceMESH
Mice, Inbred BALB CMESH
Mice, Inbred C57BLMESH
Protoporphyrins/pharmacologyMESH
T-Lymphocytes/immunologyMESH
Transplantation, HomologousMESH
Tumor Necrosis Factor-alpha/bloodMESH
Subjects:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Universitätsbibliothek Regensburg
Deposited On:20 Apr 2010 09:34
Last Modified:20 Apr 2010 09:34
Item ID:14498
Owner Only: item control page
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