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Inhibitory effect of tumor cell-derived lactic acid on human T cells

Fischer, Karin and Hoffmann, Petra and Voelkl, Simon and Meidenbauer, Norbert and Ammer, Julia and Edinger, Matthias and Gottfried, Eva and Schwarz, Sabine and Rothe, Gregor and Hoves, Sabine and Renner, Kathrin and Timischl, Birgit and Mackensen, Andreas and Kunz-Schughart, Leoni and Andreesen, Reinhard and Krause, Stefan W. and Kreutz, Marina (2007) Inhibitory effect of tumor cell-derived lactic acid on human T cells. Blood 109 (9), pp. 3812-9.

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Abstract

A characteristic feature of tumors is high production of lactic acid due to enhanced glycolysis. Here, we show a positive correlation between lactate serum levels and tumor burden in cancer patients and examine the influence of lactic acid on immune functions in vitro. Lactic acid suppressed the proliferation and cytokine production of human cytotoxic T lymphocytes (CTLs) up to 95% and led to a ...

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Item Type:Article
Date:2007
Institutions:Medicine > Abteilung für Hämatologie und Internistische Onkologie
Identification Number:
ValueType
17255361PubMed ID
10.1182/blood-2006-07-035972DOI
Classification:
NotationType
Biological Transport/immunologyMESH
Cell Cycle Proteins/immunologyMESH
Cell Proliferation/drug effectsMESH
Dose-Response Relationship, DrugMESH
FemaleMESH
Glycolysis/immunologyMESH
HumansMESH
Lactic Acid/pharmacologyMESH
Lymphocyte Activation/immunologyMESH
MaleMESH
Neoplasms/pathologyMESH
Oncogene Proteins/immunologyMESH
Spheroids, CellularMESH
T-Lymphocytes/pathologyMESH
Tumor Cells, CulturedMESH
Subjects:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Universitätsbibliothek Regensburg
Deposited On:20 Apr 2010 09:34
Last Modified:20 Apr 2010 09:34
Item ID:14499
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