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Differentiation of human tumour-associated dendritic cells into endothelial-like cells: an alternative pathway of tumour angiogenesis

Gottfried, E. ; Kreutz, M. ; Haffner, S. ; Holler, E. ; Iacobelli, M. ; Andreesen, Reinhard ; Eissner, G.



Zusammenfassung

Until recently, the only accepted mechanism of tumour vascularization was the sprouting of endothelial cells (EC) from pre-existing vessels, while recent studies suggest the contribution of stem cell-derived endothelial progenitors as well as cells from the myeloid lineage. Here, we show a new way of endothelial differentiation that involves the specific modulation of monocytes by the tumour ...

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