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Defibrotide: an endothelium protecting and stabilizing drug, has an anti-angiogenic potential in vitro and in vivo

Koehl, Gudrun E. and Geissler, Edward K. and Iacobelli, Massimo and Frei, Caroline and Burger, Verena and Haffner, Silvia and Holler, Ernst and Andreesen, Reinhard and Schlitt, Hans J. and Eissner, Günther (2007) Defibrotide: an endothelium protecting and stabilizing drug, has an anti-angiogenic potential in vitro and in vivo. Cancer biology & therapy 6 (5), pp. 686-90.

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Abstract

Defibrotide (DF) is a polydisperse mixture of 90% single-stranded oligonucleotides with anti-thrombotic and anti-apoptotic functions. DF is used in the treatment of endothelial complications in the course of allogeneic stem cell transplantation. Recent preclinical evidence suggests that DF might also have anti-neoplastic properties. In the present study we hypothesized that DF might inhibit ...

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Item Type:Article
Date:2007
Institutions:Medicine > Abteilung für Hämatologie und Internistische Onkologie
Identification Number:
ValueType
17495522PubMed ID
Classification:
NotationType
Adenocarcinoma/metabolismMESH
Angiogenesis Inhibitors/pharmacologyMESH
AnimalsMESH
Aorta/physiologyMESH
Aptamers, Nucleotide/pharmacologyMESH
Biological AssayMESH
Blotting, WesternMESH
Cell Movement/drug effectsMESH
Cell Proliferation/drug effectsMESH
Cells, CulturedMESH
Collagen/metabolismMESH
Drug CombinationsMESH
Endothelium, Vascular/metabolismMESH
HumansMESH
Laminin/metabolismMESH
MaleMESH
MiceMESH
Mice, Inbred BALB CMESH
Mice, NudeMESH
Neovascularization, Pathologic/pathologyMESH
Neovascularization, Physiologic/physiologyMESH
Phosphorylation/drug effectsMESH
Platelet Aggregation Inhibitors/pharmacologyMESH
Polydeoxyribonucleotides/pharmacologyMESH
Proteoglycans/metabolismMESH
Proto-Oncogene Proteins c-akt/metabolismMESH
RatsMESH
Rats, WistarMESH
Ribosomal Protein S6 Kinases, 70-kDa/metabolismMESH
Signal Transduction/drug effectsMESH
Stomach Neoplasms/metabolismMESH
Umbilical Veins/metabolismMESH
Vascular Endothelial Growth Factor A/metabolismMESH
Subjects:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Universitätsbibliothek Regensburg
Deposited On:20 Apr 2010 09:25
Last Modified:20 Apr 2010 09:25
Item ID:14503
Owner Only: item control page
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