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FGFR3 mutations and a normal CK20 staining pattern define low-grade noninvasive urothelial bladder tumours

van Oers, Johanna M. M. and Wild, Peter J. and Burger, Maximilian and Denzinger, Stefan and Stoehr, Robert and Rosskopf, Elke and Hofstaedter, Ferdinand and Steyerberg, Ewout W. and Klinkhammer-Schalke, Monika and Zwarthoff, Ellen C. and van der Kwast, Theodorus H. and Hartmann, Arndt (2007) FGFR3 mutations and a normal CK20 staining pattern define low-grade noninvasive urothelial bladder tumours. European urology 52 (3), pp. 760-768.

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Abstract

OBJECTIVES: Molecular markers superior to conventional clinicopathologic parameters are needed to predict disease courses in bladder cancer patients. In this study, we investigated four markers (Ki-67, TP53, CK20, FGFR3) in primary urothelial bladder tumours and compared them with traditional pathologic features. METHODS: Tissue microarrays were used to analyse CK20, TP53, and Ki-67 expression ...

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Item Type:Article
Date:2007
Institutions:Medicine > Lehrstuhl für Pathologie
Identification Number:
ValueType
17240042PubMed ID
10.1016/j.eururo.2007.01.009DOI
Classification:
NotationType
AgedMESH
Carcinoma, Papillary/pathologyMESH
DNA, Neoplasm/geneticsMESH
FemaleMESH
Follow-Up StudiesMESH
Gene Expression Regulation, NeoplasticMESH
HumansMESH
ImmunohistochemistryMESH
Keratin-20/metabolismMESH
Ki-67 Antigen/metabolismMESH
MaleMESH
MutationMESH
Neoplasm StagingMESH
Polymerase Chain ReactionMESH
Receptor, Fibroblast Growth Factor, Type 3/metabolismMESH
Retrospective StudiesMESH
Time FactorsMESH
Tumor Markers, Biological/metabolismMESH
Tumor Suppressor Protein p53/metabolismMESH
Urinary Bladder Neoplasms/pathologyMESH
Subjects:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Unknown
Created at the University of Regensburg:Unknown
Owner: Gertraud Kellers
Deposited On:03 May 2010 05:45
Last Modified:03 May 2010 05:45
Item ID:14596
Owner Only: item control page
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