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Human monocytes induce a carcinoma cell line to secrete high amounts of nitric oxide

Konur, A. and Krause, S. W. and Rehli, M. and Kreutz, M. and Andreesen, Reinhard (1996) Human monocytes induce a carcinoma cell line to secrete high amounts of nitric oxide. Journal of immunology (Baltimore, Md. : 1950) 157 (5), pp. 2109-15.

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Abstract

Nitric oxide (NO) is a short-lived pleiotropic mediator with a multitude of biologic functions. The inducible form of NO synthase (iNOS) is responsible for the discontinuous production of high amounts of NO and is important for the cytotoxic capacity of macrophages in rodents, whereas NO production by human macrophages or monocytes (MO) is under debate. Here we report that high amounts of NO are ...

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Item Type:Article
Date:1996
Institutions:Medicine > Abteilung für Hämatologie und Internistische Onkologie
Identification Number:
ValueType
8757334PubMed ID
Classification:
NotationType
Arginine/physiologyMESH
Carcinoma, Transitional Cell/secretionMESH
Coculture TechniquesMESH
Drug CombinationsMESH
HumansMESH
Interleukin-1/pharmacologyMESH
Kidney MedullaMESH
Leucine/pharmacologyMESH
Macrophage ActivationMESH
Monocytes/metabolismMESH
Nitric Oxide/metabolismMESH
Nitric Oxide Synthase/biosynthesisMESH
Nitrites/metabolismMESH
SolubilityMESH
Tumor Cells, CulturedMESH
Tumor Necrosis Factor-alpha/pharmacologyMESH
Urinary Bladder Neoplasms/secretionMESH
omega-N-Methylarginine/pharmacologyMESH
Subjects:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Universitätsbibliothek Regensburg
Deposited On:28 Apr 2010 08:52
Last Modified:28 Apr 2010 08:52
Item ID:14597
Owner Only: item control page
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