Schlitt, Hans-Jürgen and Hundrieser, J. and Hisanaga, M. and Uthoff, K. and Karck, M. and Wahlers, T. and Wonigeit, K. and Pichlmayr, R. (1994) Patterns of donor-type microchimerism after heart transplantation. Lancet 343 (8911), pp. 1469-1471.
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Allogeneic microchimerism of donor-type has been demonstrated in stable patients in the long-term after organ transplantation. We have analysed microchimerism in skin and blood of 47 heart-transplanted patients after transplantation with polymerase-chain-reaction amplification specific for donor HLA-DRB1. Microchimerism was detectable in 50% of the patients in the first 6 months, in 100% between 6 months and 2 years, and in 58% in the third postoperative year or later. The state of chimerism was not related to acute or chronic rejections. Patterns of microchimerism after heart transplantation may be dynamic, but any association with clinical and immunological variables remains to be elucidated.
|Institutions:||Medicine > Lehrstuhl für Chirurgie|
|Subjects:||600 Technology > 610 Medical sciences Medicine|
|Created at the University of Regensburg:||Unknown|
|Deposited On:||10 May 2010 12:06|
|Last Modified:||10 May 2010 12:06|