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Responsiveness for mouse IgG2b antibodies to the human alpha/beta T-cell receptor/CD3 complex: evidence for genetic determination and low grade antibody cross-linking not mediated by known Fc gamma receptors

Schlitt, Hans-Jürgen and Schwinzer, R. and Wonigeit, K. (1993) Responsiveness for mouse IgG2b antibodies to the human alpha/beta T-cell receptor/CD3 complex: evidence for genetic determination and low grade antibody cross-linking not mediated by known Fc gamma receptors. Scandinavian journal of immunology 37 (3), pp. 329-336.

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Abstract

Mouse IgG2a and IgG3 antibodies directed to the human T-cell receptor/CD3 complex stimulate peripheral blood mononuclear cells in almost all individuals. By contrast, responder and non-responder individuals exist for the stimulatory effect of mouse IgG1 and IgG2b antibodies. Whereas responsiveness to IgG1 antibodies is rather frequent (60-70%) and is known to be determined by an Fc gamma RII ...

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Item Type:Article
Date:March 1993
Institutions:Medicine > Lehrstuhl für Chirurgie
Identification Number:
ValueType
8441919PubMed ID
10.1111/j.1365-3083.1993.tb02561.xDOI
Classification:
NotationType
AnimalsMESH
Antibodies, Monoclonal/immunologyMESH
Antigen-Antibody ReactionsMESH
Antigen-Presenting Cells/immunologyMESH
Antigens, CD3/immunologyMESH
HumansMESH
Immunoglobulin G/immunologyMESH
Immunoglobulin Isotypes/immunologyMESH
MiceMESH
PedigreeMESH
Receptors, Antigen, T-Cell, alpha-beta/immunologyMESH
Receptors, Fc/immunologyMESH
Subjects:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Unknown
Created at the University of Regensburg:Unknown
Owner: Martin Kaiser
Deposited On:10 May 2010 12:12
Last Modified:13 Mar 2014 13:23
Item ID:14714
Owner Only: item control page
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