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Monoclonal antibodies to common epitopes of the human alpha/beta T-cell receptor preferentially activate CD45RA+ T-cells

Schwinzer, Reinhard and Schlitt, Hans-Jürgen and Wonigeit, Kurt (1992) Monoclonal antibodies to common epitopes of the human alpha/beta T-cell receptor preferentially activate CD45RA+ T-cells. Cellular immunology 140 (1), pp. 31-41.

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Abstract

The murine monoclonal antibody BMA 031 (IgG2b) is directed to a monomorphic epitope on the human alpha/beta T-cell receptor. In contrast to anti-CD3 antibodies of the IgG2b isotype, BMA 031 is able to induce a proliferative response in T-cells from IgG2b low responders. This response occurs independently of cross-linking conditions indicating that the mode of activation differs from stimulation ...

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Item Type:Article
Date:March 1992
Institutions:Medicine > Lehrstuhl für Chirurgie
Identification Number:
ValueType
1531453PubMed ID
10.1016/0008-8749(92)90174-NDOI
Classification:
NotationType
AnimalsMESH
Antibodies, Monoclonal/immunologyMESH
Antigens, CD/immunologyMESH
Antigens, CD3MESH
Antigens, CD45MESH
Antigens, Differentiation, T-Lymphocyte/immunologyMESH
Cell DivisionMESH
Cell LineMESH
Flow CytometryMESH
Histocompatibility Antigens/immunologyMESH
HumansMESH
Interleukin-2/pharmacologyMESH
Lymphocyte Activation/immunologyMESH
RatsMESH
Receptors, Antigen, T-Cell/immunologyMESH
Receptors, Antigen, T-Cell, alpha-beta/immunologyMESH
Receptors, Interleukin-2/analysisMESH
T-Lymphocyte Subsets/immunologyMESH
Subjects:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Unknown
Created at the University of Regensburg:Unknown
Owner: Martin Kaiser
Deposited On:10 May 2010 12:17
Last Modified:13 Mar 2014 13:23
Item ID:14718
Owner Only: item control page

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