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Ciclosporin metabolite pattern in blood and urine of kidney graft patients in relation to liver function

Bleck, J. S. and Schlitt, Hans-Jürgen and Christians, U. and Schottmann, R. and Thiesemann, C. and Strohmeyer, S. and Kohlhaw, K. and Wonigeit, K. and Pichlmayr, R. and Sewing, K. F. (1991) Ciclosporin metabolite pattern in blood and urine of kidney graft patients in relation to liver function. European journal of clinical pharmacology 40 (6), pp. 565-569.

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Abstract

Ciclosporin, an immunosuppressant, is metabolized by the liver cytochrome P450 system. Changes in the pattern of its metabolites in blood and urine in patients with disturbed liver function have been studied. Forty seven kidney graft patients receiving 2.9 mg/kg/d ciclosporin b.i.d., and no additional medication that would interfere with ciclosporin metabolism, were allocated to three groups ...

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Item Type:Article
Date:1991
Institutions:Medicine > Lehrstuhl für Chirurgie
Identification Number:
ValueType
1679393PubMed ID
10.1007/BF00279971DOI
Classification:
NotationType
Alanine Transaminase/bloodMESH
Alkaline Phosphatase/bloodMESH
Aspartate Aminotransferases/bloodMESH
Bilirubin/bloodMESH
Cholestasis/metabolismMESH
Cholinesterases/bloodMESH
Creatinine/urineMESH
Cyclosporins/urineMESH
FemaleMESH
Glutamate Dehydrogenase/bloodMESH
HumansMESH
Kidney TransplantationMESH
Liver/metabolismMESH
Liver Diseases/metabolismMESH
MaleMESH
gamma-Glutamyltransferase/bloodMESH
Keywords:Ciclosporin; metabolism; metabolites; liver dysfunction; kidney transplantation
Subjects:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Unknown
Created at the University of Regensburg:Unknown
Owner: Martin Kaiser
Deposited On:10 May 2010 12:19
Last Modified:13 Mar 2014 13:23
Item ID:14722
Owner Only: item control page

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