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Activation of human thymocytes by antibodies to the CD3/T-cell receptor complex: triggering of different epitopes results in different signals

Schwinzer, R. and Sommermeyer, H. and Schlitt, Hans-Jürgen and Schmidt, R. E. and Wonigeit, K. (1991) Activation of human thymocytes by antibodies to the CD3/T-cell receptor complex: triggering of different epitopes results in different signals. Cellular immunology 136 (2), pp. 318-328.

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Abstract

Monoclonal antibodies (mAb) against the CD3/T cell receptor (TcR) complex were analyzed for their ability to activate human thymocytes. In addition to mAb detecting epitopes on the CD3 complex (OKT3, BMA 030) the activation potential of recently developed mAb against common epitopes on the alpha/beta T-cell receptor (anti-TcR mAb: BMA 031, BMA 032) was evaluated. Several differences were observed ...

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Item Type:Article
Date:September 1991
Institutions:Medicine > Lehrstuhl für Chirurgie
Identification Number:
ValueType
1714794PubMed ID
10.1016/0008-8749(91)90355-FDOI
Classification:
NotationType
Antibodies, Monoclonal/immunologyMESH
Antigens, CD/immunologyMESH
Antigens, CD2MESH
Antigens, CD3MESH
Antigens, Differentiation, T-Lymphocyte/immunologyMESH
Calcium/physiologyMESH
EpitopesMESH
Flow CytometryMESH
HumansMESH
Lymphocyte ActivationMESH
Receptors, Antigen, T-Cell/physiologyMESH
Receptors, Immunologic/immunologyMESH
Signal TransductionMESH
T-Lymphocytes/immunologyMESH
Thymus Gland/cytologyMESH
Subjects:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Unknown
Created at the University of Regensburg:Unknown
Owner: Martin Kaiser
Deposited On:10 May 2010 12:20
Last Modified:13 Mar 2014 13:24
Item ID:14723
Owner Only: item control page
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