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Contribution of cyclosporin metabolites to immunosuppression in liver-transplanted patients with severe graft dysfunction

Schlitt, Hans-Jürgen and Christians, U. and Bleck, J. and Kohlhaw, K. and Ringe, B. and Bunzendahl, H. and Sewing, K. F. and Wonigeit, K. and Pichlmayr, R. (1991) Contribution of cyclosporin metabolites to immunosuppression in liver-transplanted patients with severe graft dysfunction. Transplant international: official journal of the European Society for Organ Transplantation 4 (1), pp. 38-44.

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Abstract

The aim of this study was to analyse the immunosuppressive contribution of cyclosporin metabolites in liver-grafted patients. Therefore the immunosuppressive potency of 17 metabolites, alone and in combination, was tested in human mixed lymphocyte cultures, and the results were correlated with metabolite blood levels in liver-grafted patients. Of the 17 metabolites tested only six highly ...

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Item Type:Article
Date:April 1991
Institutions:Medicine > Lehrstuhl für Chirurgie
Identification Number:
ValueType
1829359PubMed ID
10.1007/BF00335514DOI
Classification:
NotationType
Cyclosporins/pharmacologyMESH
HumansMESH
ImmunosuppressionMESH
Immunosuppressive Agents/pharmacologyMESH
Liver/physiopathologyMESH
Liver TransplantationMESH
Lymphocyte Culture Test, MixedMESH
Monitoring, PhysiologicMESH
Postoperative ComplicationsMESH
Keywords:Cyclosporin, role of metabolites, liver transplantation - Metabolites of cyclosporin, in liver transplantation
Subjects:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Unknown
Created at the University of Regensburg:Unknown
Owner: Martin Kaiser
Deposited On:10 May 2010 12:22
Last Modified:13 Mar 2014 13:24
Item ID:14726
Owner Only: item control page

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