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T cell activation by monoclonal antibodies directed to different epitopes on the human T cell receptor/CD3 complex: evidence for two different modes of activation

Schlitt, Hans-Jürgen and Kurrle, R. and Wonigeit, K. (1989) T cell activation by monoclonal antibodies directed to different epitopes on the human T cell receptor/CD3 complex: evidence for two different modes of activation. European journal of immunology 19 (9), pp. 1649-1655.

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Abstract

The mouse monoclonal antibody (mAb) BMA031 (IgG2b) has recently been described to be directed against a monomorphic part of the human T cell receptor (TcR) alpha/beta. In vitro analysis of its stimulatory potential for mononuclear cells revealed two patterns of responsiveness. Out of 35 tested individuals only 2 generated a proliferative response to low antibody concentrations (15 ng/ml; "high ...

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Item Type:Article
Date:September 1989
Institutions:Medicine > Lehrstuhl für Chirurgie
Identification Number:
ValueType
2477253PubMed ID
10.1002/eji.1830190920DOI
Classification:
NotationType
Antibodies, Monoclonal/immunologyMESH
Antigen-Presenting Cells/immunologyMESH
Antigens, CD3MESH
Antigens, Differentiation, T-Lymphocyte/physiologyMESH
Dose-Response Relationship, ImmunologicMESH
EpitopesMESH
HumansMESH
Immunoglobulin Isotypes/immunologyMESH
Immunologic TechniquesMESH
Lymphocyte ActivationMESH
Phorbol Esters/pharmacologyMESH
Receptors, Antigen, T-Cell/physiologyMESH
T-Lymphocytes/physiologyMESH
Subjects:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Unknown
Created at the University of Regensburg:Unknown
Owner: Martin Kaiser
Deposited On:10 May 2010 12:27
Last Modified:13 Mar 2014 13:24
Item ID:14732
Owner Only: item control page

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